Contact：chenwu@cpl.ac.cn
Education
09/2006-07/2011 Ph.D Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Specialty: Oncology
Advisor: Prof. Dongxin Lin
09/2000-07/2006 M.D China Medical University, Shenyang, China
Academic Experience
07/2018-present Tenure Professor
Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
07/2013-present Professor
Department of Carcinogenesis, National Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
09/2011-07/2013 Postdoctoral Fellow
Dept. of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Specialty: Genetic Epidemiology
Advisor: Dr. Peter Kraft & Dr. Brian Wolpin
Overview of Academic Research
Dr. Chen Wu has been focusing on cancer genetics and genomics. Her research achievements include: Leading one of the largest prospective cohort research of esophageal cancer in China with support of newly established biobank and database dedicated for cancer genome evolution research; Systematical identification of cancer susceptible genes and driver genes key to esophageal cancer initiation and development through genome-wide association study and multi-omics sequencing study; Elucidating gene functions and mechanism in carcinogenesis and cancer progression with technologies in molecular oncology, cellular biology and laboratory animal models; Integrating findings from research in pan-squamous cell carcinomas and pan-gastrointestinal cancers and identify ubiquitous target for early cancer prevention and intervention.
Major Honor and Awards
2022: XPLORER PRIZE
2021:World Economic Forum Young Global Leader, 2021 Class
2020: The State Council Special Allowance Expert
2020: National meritorious heroine model
2020: China Youth May Fourth Medal
2020:National Honor for Outstanding Medical Personnel Fighting Against COVID-19
2020: Honor for COVID-19 prevention and control in the National Health System
2020:Changjiang Scholars of the Ministry of Education
2019: Beijing Youth May Fourth Medal
2018: Outstanding Young Scientist Project
2018:The Second-class Award of National Natural Science Award
Representative Research Achievements
1. Li R#, ... , Lin D*, Huang Y*, Wang J*, Bai F*, Wu C*. A body map of somatic mutagenesis in morphologically normal human tissues. Nature. 2021 Sep;597(7876):398-403.
2. Zhang X, ... , Wu C, Lin D. Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis. Nat Commun. 2021 Sep 6;12(1):5291.
3. Lin Y, ... , Wu C, Lin D (2020). Genomic and transcriptomic alterations associated with drug vulnerabilities and prognosis in adenocarcinoma at the gastroesophageal junction. Nat Commun. 11(1): 6091.
4. Yao J, ... , Lin D, Wu C, Wang J (2020). Single-cell transcriptomic analysis in a mouse model deciphers cell transition states in the multistep development of esophageal cancer. Nat Commun. 11(1), 3715.
5. Chang J#, ... , Wu C*, Miao X*, Lin D*. Exome-wide analyses identify low-frequency variant in CYP26B1 and additional coding variants associated with esophageal squamous cell carcinoma. Nat Genet. 2018 Mar;50(3):338-343.
6. Chang J, ... , Wu C, Lin D (2017). Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations. Nat Commun 8:15290.
7. Zheng J, ... , Wu C, Lin D (2016). Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation. Nat Genet 7:11843.
8. Wei Q, ... , Wu C, Lin D (2014). Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population. Nat Genet 46:1110-1114.
9. Wu C, ... , Lin D, Taylor PR, Wang LD, Chanock SJ (2014). Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. Nat Genet 46:1001-1006.